Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

Study Source: NIH National Library of Medicine / 2016

Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-λB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-λB pathway. Doxycycline is well-tolerated, safe, and inexpensive; and is commonly used as an antibiotic and anti-inflammatory for the treatment a multitude of medical conditions.

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